Prof.dr. E.A.J.M. Goulmy (Els) Faculty    LUMC E-mail    e.a.j.m.goulmy@lumc.nl Phone    071 526 1966/38     Date of birth November 27, 1946 Place of birth Den Haag Study Medical biology, immunology Ph.D. February 14, 1985 Dissertation Recognition of human minor histocompatibility antigens by HLA restricted cytotoxic T-lymphocytes Date of accession January 1, 1999 Inaugural lecture July 2, 1999 Keep an eye on the minors Subject Transplantation biology, especially regarding minor histocompatibility antigen

Keywords

Human minor Histocompatibility antigen, leukemia, solid tumor immunotherapy, stem cell transplantation, cellular immunology

My inspiration

I am fascinated by products from ‘household’ genes that evoke strong immune responses when transferred into another individual having the same gene with only one nucleotide difference. These exciting molecules designated as 'minor Histocompatibility antigens' (mHags) pre-eminently function as tools for studying basic immunology and clinical related research. MHags transfer occurs in the physiological situation of pregnancy and in non-physiological settings such as blood transfusion, solid organ and stem cell transplantation (SCT). Our basic research focuses on all immunological aspects of mHags. The clinical related research is centred on immune reactions that mHags evoke after kidney transplantation and SCT. This combined knowledge on mHags induced tolerance, pathogenesis and the curative effects of mHags provides the basis for SCT based mHag specific anti-cancer immunotherapies for hematological malignancies and solid tumors.

Titles of major publications

• (2002) A.M. Dickinson, X.N. Wang, L. Sviland, F.A. Vyth-Dreese, G.H. Jackson, T.N.M. Schumacher, J.B.A.G. Haanen, T. Mutis, E. Goulmy, "In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens", Nature Medicine 8: 410-414.
• (1999) T. Mutis, G. Gillespie, E. Schrama, J.H.F. Falkenburg, P. Moss, E. Goulmy, "Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease", Nature Medicine 5: 839-842.
• (1998) J.M.M. den Haan, L.M. Meadows, W. Wang, J. Pool, E. Blokland, T.L. Bishop, C. Reinhardus, J. Shabanowitz, R. Offringa, D.F. Hunt, V.H. Engelhard, E. Goulmy, "The minor Histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism", Science 279: 1054-1057.
• (1996) E. Goulmy, R. Schipper, J. Pool, E. Blokland, J. Falkenburg, J. Vossen, A. Gratwohl, G. Vogelsang, H. van Houwelingen, J.J. van Rood, "Mismatches of minor histocompatibility antigens between HLA identical donor and recipient and the development of graft-versus-host disease after bone marrow transplantation", New Eng. J. Med 334: 281-285.
• (1995) J. den Haan, N. Sherman, E. Blokland, F. Koning, J.W. Drijfhout, D. Hunt, V. Engelhard and E. Goulmy, "Identification of a Graft-versus-Host Disease-associated human minor Histocompatibility antigen", Science 268: 1476-1480.

Links

http://www.lumc.nl/1090/programmes/16B16.html